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3BP / 3-BP / 3-bromopyruvate

The use of the 3BP molecule for cancer was developed at Johns Hopkins University in Baltimore, Maryland, by Young Hee Ko, PhD, a brilliant biochemist who may eventually receive a Nobel Prize for her work.

Very simply put, cancer cells eat sugar and poop out lactic acid. Dr. Ko found that the 3BP molecule can slip into the cancer cell’s pore that allows the lactic acid to get out. It blocks the lactic acid from leaving, and as the lactic acid builds up inside the cell, it destroys the cell’s ability to create any energy and thus it dies. The cancerous cell is killed from the inside. In over 100 lab tests, Dr. Ko found that 3BP performed better than all of the chemotherapy drugs she tested for comparison.

This molecule, this compound called 3-bromopyruvate or 3-BP for short, is effective when combined with the ketogenic diet which is designed to starve cancer cells of their favorite fuel, sugar.

Dayspring Cancer Clinic is the premier cancer clinic in the USA that makes 3BP available to patients with all types of cancer. Dayspring Cancer Clinic has an approved IRB (Institutional Review Board study) that enables us to make this compound available.

We believe 3BP may be the most effective alternative cancer treatment available today. 3BP works on all PET scan positive cancer cells. These cancer cells have a cellular metabolism that can be attacked by a small molecule such as 3BP. This discovery has been instrumental in propelling a new direction in cancer research focused on selectively targeting the cancer cells’ energy production factories.

At Dayspring Cancer Clinic, we work with a research team to specifically formulate 3BP for each patient, depending on each individual condition. 3BP targets the essential energy production machinery of cancer cells while leaving the same machinery in normal cells preserved.

Getting Scientific

There are two energy (ATP) production factories inside the cell:  glycolysis (getting energy from sugar/glucose) and mitochondrial oxidative phosphorylation (the use of enzymes to oxidize nutrients, thereby releasing energy).

In normal cells, about 5% of the total cellular energy production (ATP) is derived from glycolysis and about 95% from the mitochondria.[1]

In cancer cells, the energy production by glycolysis is significantly increased – up to 60%.[2] This dramatic increase in glycolysis in cancer cells results in a significant increase in lactic acid production.

Greater than 90% of cancers fit this profile (metabolic phenotype). This is called the “Warburg Effect”  – there is a significant increase in glycolysis in cancer cells even in the presence of oxygen. We see this knowledge used in PET scans (Positron Emission Tomography). Patients are given a radioactive tracer and glucose; the cancer cells predominately take up the sugar with its tracer and the resulting image shows the tumor.

Cancer cells that exhibit the “Warburg Effect” pump out their waste material, lactic acid, via a monocarboxylate transporter (MCT). The number of these transporters (think of doors or gates) in cancer cells is much greater than in normal cells.

3BP is a lactic acid analog. It is a small chemical and it mimics the lactic acid chemical structure. Therefore, like a Trojan horse, 3BP can enter through the MCTs into cancer cells. It has little effect on normal cells as these contain very few MCTs under normal physiological conditions.

Because of 3BP’s highly reactive nature, it then neutralizes the two cancer energy production factories. Cellular energy (ATP) is depleted very rapidly as 3BP attacks the two factories at the same time, causing cancer cells to die by cell membrane rupturing. Normal metabolic cells are unaffected.

Why is 3BP more beneficial than other metabolic inhibitors such as dichloroacetic acid (DCA) and/or 2-deoxyglucose (2DOG) in killing cancer cells?

The answer is based on experimental data in vitro. As a small molecule inhibitor, all three molecules can target the energy production pathways in cancer cells. However, 3BP is more effective and beneficial because:

  • 3BP is less toxic and more effective than DCA and 2DOG due to its preferential entry into cancer cells and its capacity to target simultaneously the two major energy production pathways (glycolysis and mitochondrial oxidative phosphorylation). DCA and 2DOG are more cytotoxic because they enter both normal healthy and cancerous cells. Their chemical structures do not provide for specificity to cancer cells. In fact, they enter more normal cells than cancer cells and harm normal cellular functions.
  • DCA and 2DOG are less effective than 3BP in killing cancer cells because each agent targets primarily only one of a cell’s two energy production pathways, thus allowing cells to rely on the other pathway for survival. For example, 2DOG will slow down only the glycolytic pathway but not mitochondrial function. Consequently, cancer cells will thrive utilizing mitochondrial functions. DCA improves mitochondrial function but not the glycolytic energy production pathway. Unlike 2DOG and DCA, 3BP destroys the two energy production pathways of cancer cells upon its preferential entry via monocarboxylate transporters (MCTs). That is why 3BP is much more effective than DCA and 2DOG while exhibiting little to no toxicity.

Events in Germany

In 2016, an unlicensed practitioner in Germany without any medical training (yes, that is legal) had the misfortune of allegedly causing the death of three patients with 3-bromopyruvate. Undoubtedly any time there is an unforeseen death, there is grief and pain to the family, friends, and acquaintances. Whatever happened in that troubled clinic caused consternation about the use of 3BP in the treatment of cancer.

There are no other cases of reported deaths from 3BP.

Sometimes people are quick to criticize cancer patients for trying that which is new and promising. So, let’s put a little perspective on the table.

Here’s part of an August 2016 article published in The Telegraph newspaper from the UK:

Chemotherapy warning as hundreds die from cancer-fighting drugs

Patients should be warned about the dangers of chemotherapy after research showed that cancer drugs are killing up to 50 percent of patients in some hospitals.

The study looked at more than 23,000 women with breast cancer and nearly 10,000 men with 9634 non-small cell lung cancer who underwent chemotherapy in 2014.

Some UK hospitals were using chemotherapy in ways that resulted in the death of 50% of their patients. Where was the outrage? Were murder charges brought up against those involved? No. This is conventional medicine and therefore little is said about poor outcomes; the deaths are expected and excusable.

Townsend Letter Cover

Click to read more about 3BP in the Townsend Letter

Even the seemingly safe over-the-counter drug acetaminophen (Tylenol) has a poor safety record. As early as 2004, studies were reporting that acetaminophen overdose is the leading cause for calls to Poison Control Centers across the US – more than 100,000 instances per year – and is responsible annually for more than 56,000 emergency room visits and 2,600 hospitalizations. Data from the U.S. Acute Liver Failure Study Group registry implicates acetaminophen poisoning in nearly 50% of all cases of acute liver failure (deaths) in this country. Yet it is still on the market, no warning label on

Dayspring’s goal is to give a safe, effective treatment without harm to the patient. Dayspring uses carefully measured steps to ensure patient safety. This is of utmost concern to us. What is clear to us is that in our experience, 3BP is one of the safest cancer treatments when used correctly.

We use 3BP in conjunction with a ketogenic diet, because the diet is pro-apoptotic (encourages cancer cells to die), and it alters the way the cancer cells die – they die in a more orderly fashion, with less inflammation, and less toxic release.

Protocols

We offer both a partial 3BP protocol and a full protocol.

  • The partial 3BP protocol includes three IVs a day, five days a week for four weeks. This program includes a preliminary IV for the 3BP followed by the 3BP IV itself. The third IV is flexible, depending on the patient’s greatest need. Other therapies such as heavy metal testing and dental exam may also be suggested.
  • The full 3BP protocol has the same IV schedule as the partial 3BP protocol, along with a full oral program, dental exam, hyperthermia, colonics, EWOT (Exercise With Oxygen Therapy), nutritional counseling, additional IV’s, labs, fresh pressed organic green juices, and more. It is best to have a caregiver with this protocol. If you do not have a caregiver, we can discuss other options.

Both protocols require either a port or PICC line. A PICC line can be placed at Dayspring for an additional fee.

We also offer an additional 3BP enema protocol as an add on.

There are two tests and one treatment required before beginning 3BP treatment at Dayspring:

  • Parasite treatment is necessary for all patients coming in for 3BP treatment. There are many over the counter herbal treatments that are effective in treating parasites. A prescription protocol is available upon arriving at Dayspring.
  • All patients need to take a GABA test before being given 3BP. This can be done prior to your arrival at the clinic.
  • All patients need to have a Glucose 6-Phosphate Dehydrogenase (G6PD) blood test done to determine their innate ability to handle a high dose of vitamin C. This test is done by all major lab companies. If necessary, it can be done at Dayspring, but this would cause a 2 – 3 day delay in high dose vitamin C treatment.

Dayspring may require a prior MRI of the head both with and without contrast before starting therapy.  This is to rule out a brain tumor which would cause problems with 3BP.

Feel free to call our office with any questions.

 


[1]  Lunt SY,  and Vander Heiden MG. Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation. Annual Review of Cell and Developmental Biology, Nov 2011; Vol. 27: 441-464
[2] Lis P, Ko YH, Pederson PL et al. The HK2 dependent “Warburg effect” and mitochondrial oxidative phosphorylation in cancer: Targets for effective therapy with 3-bromopyruvate. Dec 2016


References:
1 BMC Research Notes 2013, 6:277 doi:10.1186/1756-0500-6-277

2 J Bioenerg Biomembr. 2012 Feb;44(1):1-6. doi: 10.1007/s10863-012-9425-4.

3 Annual Review of Cell and Developmental BiologyVol. 27: 441-464 (Volume publication date November 2011)

4 The Hexokinase 2 Dependent “Warburg effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for effective therapy with the powerful small molecule 3-bromopyruvate. Prepublication paper June 6, 2014 Paweł Lis, Young H. Ko, Peter L. Pedersen*, Andre Goffeau and Stanisław Ułaszewski.


3BP Case Studies

Head and Neck Cancer

June 2018

A 45-year-old man with a head and neck cancer came to Dayspring for 3-bromopyruvate (3BP) after receiving proton therapy in San Diego.  The 3BP causes great pain and inflammation upon administration which is reported by the patient to be the sign of 3bp having an outstanding effect.  Unfortunately, upon beginning to receive high dose Vit C IV’s there is rapid increase in tumor growth as this patient is one of the few to have a bad response to Vit C as referenced by this 2012 study:  Mikirova N, Casciari J et al. Effect of high-dose intravenous vitamin C on inflammation in cancer patients. J Transl Med. 2012; 10: 189.

Vit C IV’s were stopped and other therapies were followed.  This patient’s emotional therapy work was rated by him as being “Epic.”  While not a typical word used to describe therapies, “Epic” shows how powerful and life changing the emotional work can be for someone. This points out the need to find and address the potential causes of the cancer.  Some of the biggest we have seen are improper dental work, heavy metals, scars, nutritional deficiencies, low thyroid not picked up by the usual conventional blood tests and of course emotions from in utero and early childhood.


Stage IV Colon Cancer

November/December 2017

A 67-year-old woman with stage IV colon cancer came to Dayspring with bilateral ostomies (a bag on both sides of abdomen). Midline surgical opening has dehisced (broken open) and become infected. CT scan is not able to give tumor dimensions as tumor is so diffuse and intertwined into abdomen. Patient was told by surgeon to go to hospice care or chemotherapy and radiation as there was nothing that could be done.

Patient stated she is not ready to die. Many difficulties are encountered during treatment:  needed to send out for a ureter stent placed by an Interventional Radiologist, worked to control the infection, packed red blood cell transfusion, and certainly many treatments for the cancer itself. These included the Tennant’s BioModulator and Transducer with his essential oils, Acuscope therapy which brought great relief from abdominal “pressure” buildup, molecular hydrogen, Amethyst BioMat, Bemer Bed, complete dental work up with extractions, pulsed harmonix PEMF, therapeutic ultrasound, LifeWave patches Severe Symptoms protocol, and many IV’s including intralipids (fats) for caloric value, Myers’ cocktails for nutrition, nanosilver, and then the combination of ozone and major autohemotherapy for the infection, ondansetron pushes for nausea, curcuma for inflammation, high dose vitamin C, and of course the “big gun” of 3-bromopyruvate (3bp) for a metabolic treatment.

Patient states she is very thankful to be at Dayspring for the care she received while here. While she still has a long way to go, she is no longer nauseous. She is now energetic enough to talk on the phone and read. She is drinking and eating more and now is able to sit comfortably; before she was not able to sit or go for a car ride. She leaves Dayspring to continue her treatment at home with an oral program, dietary information, an Amethyst BioMat, and mistletoe therapy.


Insular Glioma

October 2017

36-year-old patient came to Dayspring after resection and chemotherapy. There had been a later growth of “plumper cells” that caused patient to want to come to Dayspring for a one month “Full 3BP Protocol.” At conclusion of the month, patient went home with directions for using EWOT, David Delight Pro (brain rebalancing), encouragement to continue with colostrum, vitamin C, and BiAloe. Patient was shown information on medical cannabis for brain tumors and also subcutaneous mistletoe.


Stage IV Esophageal Cancer

September 2017

Patient had complaints of stomach pain but was ignored, told it was emotional, until given a stage IV diagnosis.

Went to a hospital in Mexico where she received vitamin C and vitamin K3 treatment along with a Gerson diet. She did very poorly on this treatment protocol and eventually came back to the USA. At this point she did 19 rounds of chemotherapy and states she thinks the chemotherapy saved her life.

Came to Dayspring for 3BP treatment and is presently doing a ketogenic diet. Arrival blood pressure was 87/64 (normal 120/80). She was treated with 3BP and also 3BP enemas plus other IVs and treatments. Electrodermal Screening (EDS) showed an extra high reading on the left second digit of the foot (the end stomach acupuncture point). Patient says she put on a toe ring at 19 or 20 years of age. Whether this was the cause of the original stomach problems is not ascertainable but patient did remove the toe ring.

Patient returned home with directions on 3BP enemas, how to treat herself with subcutaneous mistletoe, EWOT, and Biblical exhortation for mental challenges. Final blood pressure was 118/79.


Stage IV Colon Cancer

August 2017

Stage IV colon cancer came to Dayspring after having severe reactions to several chemotherapy treatments. Stated the oncologist had given a prognosis of one year to 18 months.

Dayspring presented to patient a published 2012 journal article: “A major impediment to more effective cancer treatment is the ability of tumors to acquire resistance to cytotoxic and cytostatic therapeutics, a development that contributes to treatment failures exceeding 90% [95%?, 98%?] in patients with metastatic carcinomas.” www.ncbi.nlm.nih.gov/pmc/articles/PMC3677971/pdf/nihms468571.pdf

Patient decided to do full Dayspring protocol. Upon protocol completion, patient is encouraged to do 3-bromopyruvate enemas for 6 to 9 months, subcutaneous mistletoe injections, an oral program, EWOT, and to quickly complete dental recommendations that were given by dentist in Scottsdale.


Stage IV Gastrointestinal Stromal Tumor

August 2017

Stage IV GIST (gastrointestinal stromal tumor) with hepatic metastasis; has previously been stabilized for years with cesium chloride. Has recently tried a Gerson therapy protocol with supplements.

Came to Dayspring for 3BP and specifically for the liver metastasis. After leaving Dayspring, will be doing a 3BP enema for 6 to 9 months along with other supplements and IV protocols.

Patient reports: “Thank you (much gratitude from husband and my Pops too) for taking good care of me, Doc. So lucky to have you on my side. I’m confident to live past all of the expiration dates…. I’ve already lived past the other ones given to me, right? I’ll see you again soon and bother you via email/text sooner. Thanks again for all the good, important, brave work you do.”


Malignant Lymphedema Breast Cancer

June 9, 2017

Received a text from a 56-year-old female who had left arm malignant lymphedema from a stage IV breast cancer. She had presented at clinic with extremely engorged left arm and leg as a result of her breast cancer. She decided to do an at home treatment of 3BP enemas.

The following is her text following a few weeks of her at home treatment: “The swelling is also GONE from my left arm and the left leg is right behind it…only a small amount of barely detectable swelling is left. Exciting news…. Those awful bumps I was getting all over my chest are very nearly GONE! Soon I’ll have normal healthy skin there. Go 3bp!!”


Stage IV Cholangiocarcinoma

Feb 2017

A stage IV cholangiocarcinoma (gallbladder) with a cholecystectomy cancer patient came to Dayspring. After one month of treatment in clinic, he returned home to continue his Dayspring 3BP protocol. We recently received an email that stated the following lab values:

Alk Phos had a high of 1041 now at 736
ALT had a high of 376 now at 125
GGT had a high of 1843 now at 1226

He remarked that his primary care physician (PCP) said: “First allow me to pass on a comment from my PCP that I had an appointment with yesterday. He is very impressed with recent results; while he has always been very supportive of me (for 35 years) I believe he is even more supportive and enthusiastic regarding the current treatment protocols you and I (and the team) are working on.”


Metastatic Breast Cancer

June 2016

Female, 35-years-old with metastatic breast cancer, presents to Dayspring Cancer Clinic. She was originally diagnosed and treated conventionally outside of the USA with chemotherapy and radiation.

When that did not work, she went to Nevada for treatment. When that did not work, she went to Tijuana for treatment.

When that did not work, she came to Dayspring very weak, projectile vomiting, and needing a wheelchair. Pain was significant with 60-75 mg of MS Contin daily plus Vicodin plus injectable morphine sulfate for breakout pain.

She was told very early on that she had a bad tooth and an infection. She finally agreed to go to the recommended dentist to have a tooth pulled and have the Mexican PICC line pulled because upon insertion it had caused whole body edema and a rash around the insertion site.

This was the start of her recovery. The analogy of fixing the leak in the basement first and then treating was very evident in this case. Until the leak is fixed, any attempts to refurbish the basement is futile as it will only get damaged again. “Leaks” may be, but not limited to, bad teeth, heavy metals, unresolved emotions, low thyroid (a blood test for low thyroid is like buying a used car based solely upon how much gas there is in the gas tank), poor nutrition (including GMO, food additives, low mineral content, and irradiated food), various toxicities (such as pesticides and insecticides, viral and bacterial), parasites, radiation (medical and other), polluted water (including fluoride and chlorine), tobacco, geopathic stress and EMF, etc.

Upon leaving Dayspring was off all pain meds.


Prostate Cancer stage IV

Jan 2016

We have a stage IV prostate case in clinic, unable to turn around his PSA. After taking him off of supposedly “Cassava” derived IV vitamin C and putting him on an oral true Cassava derived vitamin C, his PSA went from 570 to 204 in 11 days. That is a 64% drop in PSA in eleven days!

It is very critical to get true non-corn vitamin C. That is very difficult as compounding pharmacies have no way to establish whether or not the C of A (certificate of analysis) is honest or not. After all, the pharmacy depends on the supplier to be truthful and the supplier has to depend on others to do the same. At some point, this line of trust may be broken by unscrupulous people. Cassava derived vitamin C is about 5-6 times the price of corn derived vitamin C. Who is to say what is really coming out of China? I have been in contact with a European food analytical company and they are saying that a SNIF- NMR analysis will not work to see the true source of vitamin C. Ultimately what the person in charge said was, “Unfortunately, I do not know, how this challenge could be assessed.” So buyer beware, just because a C of A says “Cassava derived” does not mean it is verifiable and not as efficacious as a true Cassava derived product.


Triple Negative Breast Cancer

Jan 2016

A patient with triple negative breast cancer comes in to Dayspring. Originally diagnosed as a DCIS, the lumpectomy is upgraded to a triple negative breast cancer. During the first phone call, she immediately breaks down into heavy sobbing, saying that her oncologist had told her that without chemotherapy and radiation she would be dead in two years. Not wanting the chemotherapy toxicity and radiation damage, she comes to Dayspring for 3-bromopyruvate (3BP) treatment.

What she learns is that chemotherapy does not kill cancer stem cells, that stem cells can continue after chemotherapy and start a new tumor. 3BP goes after the metabolism of cancer cells, not just cellular division as in chemotherapy. With the 3BP treatment protocol, dietary education, and a strong supplemental program, she will be able to have a superb outcome.


Stage III Invasive Ductal Carcinoma Breast Cancer

Patient came to clinic specifically for 3BP treatment. She has done multiple IPT chemotherapy treatments. An immunotherapy treatment has left her with a calcified breast mass 10 x 12 x 4 cm. Patient is extremely steadfast about not having a mastectomy. Left axilla has a 1 x 2 cm lymph node.

Patient begins 3bp treatment and in two weeks lymph node is no longer palpable. Breast calcification is a solid mass and patient is told that it will take time for mass to be reabsorbed by the body.

Patient finished treatment and stated that she “feels like she is 15 years younger and healthier than she has been in years.” Also that her skin is clearer and that she has more energy.

Markers have surprisingly not moved significantly but patient states that if the cancer is not totally gone then we really “kicked its butt” from her perspective. States that the IPT treatments determined from the Greek test did not nearly give the same positive response as the treatments of 3BP.

She states she is wanting to come to Dayspring as needed at some time in the future.


Pancreatic Cancer Stage 4

Feb 2015

68-year-old man with upper intermittent left quadrant abdominal pain, 46 lbs weight loss and insomnia. Upon arrival at clinic, CA 19-9 Lab test = 530 (<35 is normal) Sonora Quest Laboratories.

Prior to clinic in Jan 2015 had 4 chemotherapy sessions, Gemcitabin and Oxaliplatin.

Diagnosis: Pancreatic mass (5.7 by 4.1cm) of the body and portions of the tail of the pancreas. Possible liver metastasis due to mildly complex lesion. Very Poor Short Term Prognosis

2/16/2015 through 3/14/2015 Patient utilized 3BP, IV’s, an oral protocol, hyperthermia, EWOT, fresh green juices, colonics, etc.

3/10/2015 Follow-up CA 19-9 now 202, 20% per week reduction (60% cumulative) in three weeks. Unfortunately last blood draw at week #4 was missed. Patient has to leave to go back home and will continue oral program.

On 4/13/15 patient reports CA 19-9 is now 126, which is a 75% reduction in his original blood marker. He decided to not do any chemotherapy and continue the oral program.

7/30/2015:  Patient finally did do chemotherapy at home and tumor marker hit a high of 1,574 and chemotherapy was stopped. He is now doing 3BP along with other products to support the 3BP. With this regimen his CA 19-9 is now down to 244.

He writes: “If this ends happily (whenever you can tell that might be a philosophical question) I will really address the question how it is possible to ignore a miraculous agent like 3-BP for now 15 years whilst people are dying in en mass. This is really unbelievable.”

Update 10/31/15

Patient reports via email: “Just some update. I am feeling quite well with no pain. The good thing is that the tumor seems not to be growing and the bad thing is that it does not seem to be decreasing either. As you can see from the Lab rep CA19-9 is actually slightly decreasing which of course is encouraging.”

He was encouraged to continue with his supplementation plan and was encouraged to not be discouraged by imaging size as scar tissue and tumor modification can take time to dissipate.


Stage IV Breast to Bone

Dec 2014

PET shows primary lesion in right breast and secondary lesions in the sternum, T11, L2 and pubic ramus. Estrogen (+), Progesterone (+), Her 2 (-) immunohistochemical staining. Debilitating pain in the area of T11 with ablation. Taking Dilaudid for pain and has a walker.

Starts Dayspring protocol 12/18/15 with 3BP and other IVs.

In two weeks, back pain is resolved and walker is never used. Leaves clinic after one month of treatment.

4/15 Dayspring receives report that the breast lesion is gone and the bone metastasis have only small lymphocytic rings around the lesions.

7/5/15 Patient states: “I’m actually feeling better than I have in years. Hard to believe I have cancer.”

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